SKU: S101  / 
    CAS Number: 154589-96-5

    Stauprimide

    $319.50 - $1,113.50
    Stauprimide
    • Detailed Description

      CAS Number: 154589-96-5

      Molecular Formula: C35H28N4O5

      Molecular Weight: 584.6

      Mechanism of Action: Stauprimide interacts with NME2 (PUF) transcription factor to down-regulate c-Myc expression, leading to differentiation of stem cells.

      Storage Conditions: -20°C

    • Specifications

      Appearance: Yellow orange solid

      Purity Level: >95% by HPLC

    • References

      References: Inhibitory activity and selectivity of staurosporine derivatives towards protein kinase C. Caravatti G. et al. , Bioorg. Med. Chem. Letters 1994, 4, 399.

      A small molecule primes embryonic stem cells for differentiation. Zhu S. et al. , Cell Stem Cell 2009, 4, 416

    Stauprimide is a semi-synthetic analogue of the staurosporine family of indolocarbazoles. Stauprimide was first published in 1994 as part of an extensive structure-activity investigation to improve the selective inhibition of protein kinase C as potential antitumor agents. Stauprimide increases the efficiency of the directed differentiation of mouse and human embryonic stem cells in synergy with defined extracellular signalling cues.

    Stauprimide is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number: 154589-96-5

    Molecular Formula: C35H28N4O5

    Molecular Weight: 584.6

    Mechanism of Action: Stauprimide interacts with NME2 (PUF) transcription factor to down-regulate c-Myc expression, leading to differentiation of stem cells.

    Storage Conditions: -20°C

    Appearance: Yellow orange solid

    Purity Level: >95% by HPLC

    References: Inhibitory activity and selectivity of staurosporine derivatives towards protein kinase C. Caravatti G. et al. , Bioorg. Med. Chem. Letters 1994, 4, 399.

    A small molecule primes embryonic stem cells for differentiation. Zhu S. et al. , Cell Stem Cell 2009, 4, 416