Streptimidone (protomycin) is a glutarimide antibiotic isolated from Streptomyces spp. first reported in 1959. Streptimidone is active against a wide spectrum of fungi and protozoans, including Entamoeba hystolica in vitro and in vivo. Streptimidone also exhibits herbicidal activity against several monocotyledons in the preemergent phase. Streptimidone acts as an inihibitor of protein biosynthesis by binding to 80S ribosomes.
Hirabayashi A (1959) The antiamebic effect of protomycin, a new antibiotic isolated from the culture filtrate of a species of streptomycetes. J. Antibiot. Ser. A 12:298
Kim BS et al (1999) Isolation, antifungal activity, and structure elucidation of the glutarimide antibiotic, streptimidone, produced byMicromonospora coerulea. J. Agric. Food Chem. 47:3372
Kohberger D.L (1960) Biological studies of streptimidone, a new antibiotic. Antibiot. Chemother. 10:9
Taylor WR et al (1982) Inhibitors of protein synthesis on 80S ribosomes phase shift the gonyaulax clock. J. Exp. Biol. 97:121