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Detailed Description
CAS Number: 68-35-9
Molecular Formula: C10H10N4O2S
Molecular Weight: 250.28 g/mol
Mechanism of Action: Sulfadiazine is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. This enzyme is needed for the proper processing of para-aminobenzoic acid (PABA) which is essential for folic acid synthesis. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Storage Conditions: 2-8°C
Tariff Code: 2935.00.4200
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Specifications
Form: Powder
Appearance: White or almost white crystalline powder.
Source: Synthetic
Assay: (on dried basis): 99.0% - 101.0%
Residue On Ignition: Less than 0.1%
Heavy Metals: Less than 10 ppm
Loss on Drying: Less than 0.5%
Identification: Conforms
Purity Level: ≥99.0%
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Technical Data
Impurity Profile: Impurity A| Pyrimidin-2-amine|109-12-6|C4H5N3|95.1| Impurity B| 4-Aminobenzenesulfonic Acid (Sulphanilic Acid)|121-57-3|C6H7NO3S|173.19| Impurity D| 4-Aminobenzenesulfonamide (Sulfanilamide)|63-74-1|C6H8N2O2S|172.20| Impurity UN1| N4-Acetylsulfadiazine|5572-57-6|C12H12N4O3S|292.31|
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References
References:
"Sulfadiazine: Mechanism of Action." Cancer News Network. N.p., 2009. Web. 21 Aug. 2012.
Tabatabaei, I., Dal Bosco, C., Bednarska, M., Ruf S., Meurer, J., Bock, R. (2018) A highly efficient sulfadiazine selection system for the generation of transgenic plants and algae. Plant Biotechnol. J., https://doi.org/10.1111/pbi.13004
Minden, V., Deloy, A., Volkert, A. M., Leonhardt, S. D., & Pufal, G. (2017). Antibiotics impact plant traits, even at small concentrations. AoB PLANTS, 9(2), plx010. doi:10.1093/aobpla/plx010
Sulfadiazine is a sulfonamide antibiotic that was developed in 1940 by Richard Roblin at the Stamford Research Laboratories of the American Cyanamid Company to be a more potent and less toxic alternative to Sulfapyridine. Sulfadiazine is a bacteriostatic folic acid synthesis inhibitor that shows broad spectrum activity against gram-positive bacteria, gram-negative bacteria and Chlamydia.
Sulfadiazine is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. This enzyme is needed for the proper processing of para-aminobenzoic acid (PABA) which is essential for folic acid synthesis. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Sulfadiazine is sparingly soluble in aqueous solution (0.077 mg/mL).
Synonyms: 4-Amino-N-(2-pyrimidinyl)benzenesulfonamide, N1-(Pyrimidin-2-yl)sulfanilamide
CAS Number: 68-35-9
Molecular Formula: C10H10N4O2S
Molecular Weight: 250.28 g/mol
Mechanism of Action: Sulfadiazine is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. This enzyme is needed for the proper processing of para-aminobenzoic acid (PABA) which is essential for folic acid synthesis. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Storage Conditions: 2-8°C
Tariff Code: 2935.00.4200
Form: Powder
Appearance: White or almost white crystalline powder.
Source: Synthetic
Assay: (on dried basis): 99.0% - 101.0%
Residue On Ignition: Less than 0.1%
Heavy Metals: Less than 10 ppm
Loss on Drying: Less than 0.5%
Identification: Conforms
Purity Level: ≥99.0%
Impurity Profile: Impurity A| Pyrimidin-2-amine|109-12-6|C4H5N3|95.1| Impurity B| 4-Aminobenzenesulfonic Acid (Sulphanilic Acid)|121-57-3|C6H7NO3S|173.19| Impurity D| 4-Aminobenzenesulfonamide (Sulfanilamide)|63-74-1|C6H8N2O2S|172.20| Impurity UN1| N4-Acetylsulfadiazine|5572-57-6|C12H12N4O3S|292.31|
References:
"Sulfadiazine: Mechanism of Action." Cancer News Network. N.p., 2009. Web. 21 Aug. 2012.
Tabatabaei, I., Dal Bosco, C., Bednarska, M., Ruf S., Meurer, J., Bock, R. (2018) A highly efficient sulfadiazine selection system for the generation of transgenic plants and algae. Plant Biotechnol. J., https://doi.org/10.1111/pbi.13004
Minden, V., Deloy, A., Volkert, A. M., Leonhardt, S. D., & Pufal, G. (2017). Antibiotics impact plant traits, even at small concentrations. AoB PLANTS, 9(2), plx010. doi:10.1093/aobpla/plx010
