Tedizolid Phosphate is an oxazolidone antibiotic. It is a phosphate ester prodrug of Tedizolid, the active compound. It is bacteriostatic against Gram-positive organisms.
|Mechanism of Action||Tedizolid binds to the 23S rRNA of the 50S ribosomal subunit, preventing the formation of the 70S initiation complex and inhibiting protein synthesis.|
|Spectrum||Effective against Gram-positive bacteria including MRSA and VRE, and linezolid-resistant strains|
|Microbiology Applications||Tedizolid inhibited all 28 isolates of penicillin-resistant Streptococcus pneumoniae using an in vitro mouse model with 0.25 µg/mL, which was 4-fold more potent than Linezolid (Choi et al, 2012).|
|Solubility||Soluble in DMSO (36 mg/mL), sparingly soluble in water (0.1 mg/mL)|
|References||Choi S, Im W, and Bartizal K (2012) Activity of tedizolid phosphate (TR-701) in murine models of infection with penicillin-resistant and penicillin-sensitive Streptococcus pneumoniae. Antimicrob Agents Chemother. 2012 Sep;56(9):4713-7 PMID 22713339 Kisgen JJ, Mansour H, Unger NR, Childs LM (2014) Tedizolid: a new oxazolidinone antimicrobial. Am. J. Health Syst. Pharm. 71(8):621-33 PMID 24688035 Rybak JM, Marx K, Martin CA (2014) Early experience with tedizolid: Clinical efficacy, pharmacodynamics, and resistance. Pharmacother. 34(11):1198-208 PMID 25266820|