Terpendole I is a polar analog of a rare family of indolediterpenes isolated from Albophoma yamanashiensis, first reported by Omura and colleagues at the Kitasato Institute, Japan in 1995. Terpendole I is a weak inhibitor of ACAT (acylCoA:cholesterol acyltransferase). The biosynthetic gene cluster coding for production of terpendoles was identified in 2012.
| Molecular Formula | C27H35NO5 |
| References | Kobayashi T. et al. (1994) Materials for the fungus flora of Japan (47). , Mycoscience 35:399 Motoyama T. et al (2012) Terpendole E, a kinesin Eg5 inhibitor, is a key biosynthetic intermediate of indole-diterpenes in the producing fungus Chaunopycnis alba. Chem. Biol. 19:1611 Tomoda H et al (1995) Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. III. Production, isolation and structure elucidation of new components. J. Antibiot. 48:793 |
