SKU: T083  / 
    CAS Number: 582-46-7

    Terrein

    $168.64 - $590.25
    Terrein is a polar, substituted dihydrocyclopentenone first reported by Raistrick and colleagues in the 1930s and subsequently found in a number of Aspergillus and Penicillium species.

    Terrein is soluble in ethanol, methanol, DMF and DMSO.
    Mechanism of ActionRecent research shows that terrein reduces melanin synthesis by reducing tyrosinase production via ERK activation, followed by MITF down-regulation. Terrein also reduces human keratinocyte proliferation by inhibiting ERK and by decreasing the expression of cyclin B1 and Cdc2 complex.
    ReferencesStudies in the biochemistry of micro-organisms: The metabolic products of Aspergillus terreus Thom. A new mould metabolic product, terrein. Raistrick H. & Smith G. Biochem. J. 1935, 29, 606.

    Terrein: a new melanogenesis inhibitor and its mechanism. Park S.H. et al. Cell. Mol. Life Sci. 2004, 61, 2878.

    Terrein inhibits keratinocyte proliferation via ERK inactivation and G2/M cell cycle arrest. Kim D.S. et al. Exp. Dermatol. 2008, 17, 312.