Thaxtomin A is a unique dioxopiperazine containing a 4-nitroindol-3-yl moiety isolated by scientists at Dow Agrisciences from Streptomyces scabies, the causative agent of common scab on new potatoes in 1989. Thaxtomin A is the predominant and most active member of the thaxtomin group of phytotoxins. Thaxtomin A acts as a herbicide via inhibition of cellulose biosynthesis. Atypical programmed cell death induced by Thaxtomin A can be ameliorated by hydrogen peroxide. Thaxtomin A dysregulates K+ and Ca2+ fluxes in the roots of Arabidopsis.
| Molecular Formula | C22H22N4O6 |
| References |
Awwad F et al (2019) Reactive oxygen species alleviate cell death induced by thaxtomin A in Arabidopsis thaliana cell cultures. Plants 8:332 King RR et al (1989) Isolation and characterization of phytotoxins associated with Streptomyces scabies. J. Chem. Soc. Chem. Commun. 849 King RR and Lawrence CH (2001) Herbicidal properties of the thaxtomin group of phytotoxins. J Agric Food Chem. 49:2298 |