SKU: T011  / 
    CAS Number: 738-70-5

    Trimethoprim

    $89.00 - $1,126.00

    Trimethoprim is a synthetic derivative of trimethoxybenzyl-pyrimidine with bacteriostatic and antiprotozoal properties. As a dihydrofolate reductase inhibitor, trimethoprim binds tightly to the bacterial enzyme, blocking the production of tetrahydrofolic acid from dihydrofolic acid, arresting folic acid synthesis.

    When Trimethroprim is combined with sulfonamides, like Sulfamethoxazole (S045), the two compounds show bactericidal effects, but are only bacteriostatic when used separately. The activity is attributed to their synergistic effect in inhibiting folic acid metabolism in bacteria. 

    Trimethoprim has a wide antibacterial spectrum and is active against most Gram-positive and Gram-negative aerobic bacteria, including NocardiaBrucella, Gram-negative bacilli, and some Gram-positive bacteria like StreptococcusToxoplasma and some other coccidians. It is used to treat recurrent cystitis, mild acute prostatitis, urinary tract infections, asymptomatic bacteriuria during pregnancy and respiratory tract infections. The product is very slightly soluble in aqueous solution.

    We also offer:

    • Trimethoprim Lactate (T012)