Trimethoprim Lactate is a synthetic derivative of trimethoxybenzyl-pyrimidine with bacteriostatic and antiprotozoal properties. As a pyrimidine inhibitor of bacterial dihydrofolate reductase, Trimethoprim binds tightly to the bacterial enzyme, blocking the production of tetrahydrofolic acid from dihydrofolic acid, arresting folic acid synthesis.
When Trimethroprim Lactate is combined with sulfonamides like Sulfamethoxazole (S045) the compounds show bactericidal effects, but are only bacteriostatic when used separately. The activity is attributed to their synergistic effect in inhibiting folic acid metabolism in bacteria and thus blocking nucleotide biosynthesis.
Trimethoprim Lactate is broad-spectrum and is active against most Gram-positive and Gram-negative aerobic bacteria, including Nocardia, Brucella, Gram-negative bacilli, and some Gram-positive bacteria like Streptococcus, Toxoplasma and some other coccidians. It is active against the bacteria causting cystitis, mild acute prostatitis, and urinary tract infections. The compound is used as a selection agent in research applications.
Trimethoprim Lactate is freely soluble in aqueous solution.
We also offer:
- Trimethoprim (T011)
