SKU: T101  / 
    CAS Number: 7561-71-9

    Trinactin

    $314.50 - $1,098.00
    Trinactin
    • Detailed Description

      CAS Number: 7561-71-9

      Molecular Formula: C43H70O12

      Molecular Weight: 779.0

      Mechanism of Action: Trinactin inhibits T-cell proliferation induced by IL-2, and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-γ.

      Storage Conditions: -20°C

    • Specifications

      Appearance: Colourless Film

      Purity Level: >95% by HPLC

    • References

      References: Effects of cyclosporin A and dinactin on T-cell proliferation, interleukin-5 production, and murine pulmonary inflammation. Umland S. P., et al. , Am. J. Respir. Cell Mol. Biol., 1999, 20, 481.

      Immunosuppressive effects of polynactins (tetranactin, trinactin and dinactin) on experimental autoimmune uveoretinitis in rats. Tanouchi Y., et al. , Jpn. J. Ophthalmol., 1987, 31, 218.

      Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin. Graven S. N., et al. , Biochemistry, 1966, 5, 1735.

    Trinactin is a member of the macrotetrolide complex produced by a range of Streptomyces sp.. Early literature reported that trinactin was a monovalent cation ionophore with high selectivity for ammonium and potassium. Trinactin has not previously been available for intensive investigation.

    Trinactin is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number: 7561-71-9

    Molecular Formula: C43H70O12

    Molecular Weight: 779.0

    Mechanism of Action: Trinactin inhibits T-cell proliferation induced by IL-2, and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-γ.

    Storage Conditions: -20°C

    Appearance: Colourless Film

    Purity Level: >95% by HPLC

    References: Effects of cyclosporin A and dinactin on T-cell proliferation, interleukin-5 production, and murine pulmonary inflammation. Umland S. P., et al. , Am. J. Respir. Cell Mol. Biol., 1999, 20, 481.

    Immunosuppressive effects of polynactins (tetranactin, trinactin and dinactin) on experimental autoimmune uveoretinitis in rats. Tanouchi Y., et al. , Jpn. J. Ophthalmol., 1987, 31, 218.

    Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin. Graven S. N., et al. , Biochemistry, 1966, 5, 1735.