SKU: T107  / 
    CAS Number: 217500-96-4

    Tulathromycin A

    $72.10 - $437.75

    Tulathromycin is a semi-synthetic derivative of erythromycin belonging to the ring expanded aza-erythromycins. Ring expansion improves the acid lability compared with the parent erythromycins. Tulathromycin is regarded as the first of the triamilides, structurally similar to azithromycin and having a third amino (propylaminomethylene) group on a sugar to improve absorption. This modification provides a stable mixture of Tulathromycin isomers when in aqueous solution, in a 9:1 ratio.  Tulamycin A (CP-472,295 a 15-ring member) is the major component, and Tulathromycin B (CP-547,272, a 13-ring member) the minor component.  It is used in animal research applicaitons, and is active against the bacteria causing bovine and swine bacterial respiratory diseases. LC-MS methods have been reported for Tulathromycin in plasma and tissue samples in cattle, swine, goats, and foals.

    Tulathromycin A is soluble in ethanol and DMSO but is practically insoluble in water.

    Molecular Formula C41H79N3O12
    Mechanism of Action Tulathromycin A binds to the 50S subunit of the bacterial ribosome, interfering with bacterial protein synthesis.
    Spectrum Tulathromycin A is effective against Gram-negative bacteria with mixed bacteriostatic and bactericidal activity.
    Eukaryotic Cell Culture Applications Tulathromycin A was used to assess primary DNA damage using in vitro Comet assay in isolated rat lymphocytes. Lymphocytes were treated with Tulathromycin (1-100 µM) and co-treatment with an antioxidant, catalase (100 IU/ml and 500 IU/ml). The highest concentrations of Tulathromycin (50 and 100 µM) caused significant increase of DNA damage in rat lymphocytes and catalase did not significantly reduce the DNA-damaging effect of Tulathromycin. The results of this study indicate that Tulathromycin induces genotoxic effects at high concentrations and catalase does not exert protective effect in this case (Jelena, 2015).
    References

    Boison JO (2016) A single laboratory-validated LC-MS method for the analysis of Tulathromycin residues in bison and deer sera and selected tissues of white-tailed deer. Drug Test Analysis 8:584-595

    Evans NA (2005) Tulathromycin: An overview of a new triamilide antibiotic for livestock respiratory disease. Vet Ther. Summer 6(2):83-95 PMID 16094557

    Gáler D et al (2004)  An analytical method for the analysis of Tulathromycin, an equilibrating triamilide, in bovine and porcine plasma and lung. J. Agric. Food Chem. 52:2179

    Jelena M (2015) Evaluation of DNA damage in rat lymphocytes exposed to Tulathromycin in vitro. Genetica. 47(1):339-348

    Letavic MA et al (2002) Synthesis and activity of a novel class of tribasic macrocyclic antibiotics: The triamilides. Bioorg. Med. Chem. Lett. 12:2771