SKU: U006  / 
    CAS Number: 121569-61-7

    UCN-02

    $277.35 - $970.71
    UCN-02 is an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite. Although less selective than its isomer UCN-01, UCN-02 exhibits comparable activity and probably acts by similar mechanisms.

    UCN-02 is soluble in ethanol, methanol, DMF and DMSO. 
    Molecular FormulaC28H26N4O4
    ReferencesUCN-01-induced cell cycle arrest requires the transcriptional induction of p21waf1/cip1 by activation of mitogen-activated protein/extracellular signal-regulated kinase/extracellular signal-regulated kinase pathway. Facchinetti M. M. et al. Cancer Res. 2004, 64, 3629. 

    UCN-01 (7-hydroxystaurosporine) and other indolocarbazole compounds: a new generation of anti-cancer agents for the new century? Akinaga S. et al. Anticancer Drug Des. 2000, 15, 43. 

    UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities. Takahashi I. et al. J. Antibiot. 1989, 42, 571.