SKU: V026  / 
    CAS Number: 56124-62-0

    Valrubicin

    $293.09 - $984.17

    Valrubicin is a semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin.  It is used for cancer research in models of bladder cancer.

    Mechanism of Action Valrubicin is converted into N-trifluoroacetyladriamycin, which interacts with topoisomerase II, an enzyme that relaxes DNA supercoils. DNA replication and repair is inhibited, which prevents RNA synthesis and protein production, resulting in cell cycle arrest in phase G2. Valrubicin also accumulates in the cytoplasm where it inhibits protein kinase C.
    Molecular Formula C34H36F3NO13
    References

    Onrust CV and Lamb HM (1999)  Valrubicin. Drugs Aging 15:69-75

    Sabnis N et al (2012) Enhanced solubility and functionality of valrubicin (AD-32) against cancer cells upon encapsulation into biocompatible nanoparticles. Int. J. Nanomed. 7:975-983