Virginiamycin S1 is a cyclic hexadepsipeptide. Together with Virginiamycin M1 as a mixture, it works synergistically against Gram-positive bacteria with bateriostatic properties. Commercial preparations of Virginiamycin is 25% S1 and 75% M1. Virginiamycin S1 differs from Virginiamycin B in that it lacks the dimethylamino moiety of the phenyl ring. Virginiamycin S1 is soluble in ethanol, methanol, DMSO, and DMF.
|Mechanism of Action||Virginiamycin S1 binds to the bacterial 50S ribosomal subunit, preventing aminoacyl-tRNA binding and peptide bond formation, thus inhibiting protein synthesis. The visG gene is required for biosynthesis of Virginiamycin S1.|
|References||Vanderhaeghe, H. et al. (1971) The structures of the minor components of virginiamycin S. Tet. Lett. 2687|
Crooy P. and De Neys R. J. (1972) Virginiamycin: nomenclature. J. Antibiot.(Tokyo) 25(6):371-372 PMID 4568014
Ogata, K et al (1978) A new species of Streptomyces producing virginiamycin family antibiotics.. Antibiot. (Tokyo) 31(2):1313-1315 PMID 162634