SKU: V014  / 
    CAS Number: 23152-29-6

    Virginiamycin S1

    $277.35 - $970.71

    Virginiamycin S1 is a cyclic hexadepsipeptide.  Together with Virginiamycin M1 as a mixture, it works synergistically against Gram-positive bacteria with bateriostatic properties.  Commercial preparations of Virginiamycin is 25% S1 and 75% M1.  Virginiamycin S1 differs from Virginiamycin B in that it lacks the dimethylamino moiety of the phenyl ring.  Virginiamycin S1 is soluble in ethanol, methanol, DMSO, and DMF.

    Mechanism of ActionVirginiamycin S1 binds to the bacterial 50S ribosomal subunit, preventing aminoacyl-tRNA binding and peptide bond formation, thus inhibiting protein synthesis. The visG gene is required for biosynthesis of Virginiamycin S1.
    Molecular FormulaC43H49N7O10
    ReferencesVanderhaeghe, H. et al. (1971)  The structures of the minor components of virginiamycin S. Tet. Lett. 2687

    Crooy P. and De Neys R. J. (1972)  Virginiamycin: nomenclature. J. Antibiot.(Tokyo) 25(6):371-372  PMID 4568014 

    Ogata, K et al  (1978)  A new species of Streptomyces producing virginiamycin family antibiotics.. Antibiot. (Tokyo) 31(2):1313-1315  PMID 162634