Sulochrin is a fungal metabolite isolated from a number of Aspergillus and Penicillium sp.. An anti-angiogenic agent, sulochrin inhibits VEGF leading to inhibition of capillary-like tube formation of human umbilical vein endothelial cells. Sulochrin also inhibits eosinophil activation and chemotaxis.
Sulochrin is soluble in ethanol, methanol, DMF and DMSO.
Sulochrin is soluble in ethanol, methanol, DMF and DMSO.
| References | Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor (VEGF)-induced tube formation of HUVECs. Lee H.J. et al. J. Antibiot. 2002, 55, 552. Effects of ortho-substituent groups of sulochrin on inhibitory activity to eosinophil degranulation. Ohashi H. et al. Bioorg. Med. Chem. Lett. 1999, 9, 1945. Sulochrin inhibits eosinophil activation and chemotaxis. Ohashi H. et al. Inflamm. Res. 1998, 47, 409. |
