Dehydrocurvularin is a 12-membered macrocyclic lactone incorporating a resorcinyl moiety, produced by a number of fungal species including Curvularia, Penicillium and Alternaria. Dehydrocurvularin inhibits cell division by disrupting mitotic spindle formation and acts as a developmental regulator by inhibiting self-sporulation in Alternaria alternata. More recently dehydrocurvularin has been shown to have antimalarial activity.
Dehydrocurvularin is soluble in ethanol, methanol, DMF and DMSO.
Dehydrocurvularin is soluble in ethanol, methanol, DMF and DMSO.
| References | Curvularin. Part V. The compound C16H18O5, α,β-dehydrocurvularin. Munro H.D. et al. J. Chem. Soc. 1967, 947. Isolation of alpha, beta-dehydrocurvularin and, beta-hydroxycurvularin from Alternaria tomato as sporulation suppressing factors. Hyeon S-B. et al. Agri. Biol. Chem. 1976, 44, 1663. Betagamma-dehydrocurvularin and related compounds as nematocides of Pratylenchus penetrans from the fungus Aspergillus sp. Kusano M. et al. Biosci. Biotechnol. Biochem. 2003, 67, 1413. |