15-Acetyldeoxynivalenol is a trichothecene mycotoxin produced by Fusarium sp. infecting cereals and grains and posing a health risk to humans and livestock. 15-Acetyldeoxynivalenol has lower acute oral toxicity than deoxynivalenol in mice. In a comparative study of the effects of deoxynivalenol and its 3- and 15-acetyl derivatives on transepithelial transport, gene expression, and cytokine secretion in human intestinal cell Caco-2, all metabolites could induce mRNA expression and production of IL-8, with 15-acetyldeoxynivalenol causing the highest permeability and IL-8 secretion.
| Molecular Formula | C17H22O7 |
| References |
Forsell JH et al (1987) Comparison of acute toxicities of deoxynivalenol (vomitoxin) and 15-acetyldeoxynivalenol in the B6C3F1 mouse. 25:155 Kadota T et al. (1888) Comparative study of deoxynivalenol, 3-acetyldeoxynivalenol, and 15-acetyldeoxynivalenol on intestinal transport and IL-8 secretion in the human cell line Caco-2. Toxicol. In Vitro 27:1888 |
