2-Oxazolidone is a heterocyclic organic compound containing nitrogen and oxygen in a 5-membered ring. The Oxazolidinone class has a 2-Oxazolidone in the structure and can be used as antimicrobials. Other important oxazolidinone antibiotics include Linezolid, Tedizolid, Posizolid, Radezolid, Cycloserine, and Contezolid. In chemistry, they can be used as Evans auxiliaries, which are used for chiral synthesis. It can be used as a precursor for the preparation of other compounds and commercially important intermediates such as N-vinyl-2-oxazolidone.
2-Oxazolidone is soluble in water.
| Mechanism of Action | 2-Oxazolidone acts by inhibiting protein synthesis, targeting the binding of N-formylmethionyl-tRNA to the ribosome. |
| Spectrum | 2-Oxazolidone is effective against Gram-positive bacteria including MRSA, penicillin-resistant streptococci, and vancomycin-resistant enterococci. |
| References |
Pandit N, Singla RK and Shrivastava B (2012) Current updates on Oxazolidinone and its significance. Int. J. Med. Chem. ID 159285 PMID 25954524 Vani PVSN et al (2000) Synthesis of N-vinyl-2-oxazolidone: A commercially important intermediate. Int. J. Rapid Comm. Synthetic Org. Chem. 31(13):2043-2046 |
