2-Benzoxazolinone is a metabolite produced by rye (Secale cereale) that inhibits germination and growth and causing oxidative damage. 2-Benzoxazolinone has diverse pharmacological activities including antinociception, anti-inflammatory, antileishmanial, antioxidant, anti-HIV, anticancer, antidepressant, and neuroprotective effects. 2-Benzoxazolinone is a sought-after structure for the design of bioactive molecules. 2-Benzoxazolinone is soluble in methanol and DMSO.
|Mechanism of Action||2-Benzoxazolinone targets the G2/M phase of the cell cycle.|
|Plant Biology||The natural compound inhibits the cell cycle in lettuce root meristems (Sanchez et al, 2008). Early senescence is induced by 2-3H-benzoxazolinone (BOA) in Arabidopsis thaliana (Sanchez et al, 2011).|
Sánchez-Moreiras A-M (2008) The natural compound benzoxazolin-2(3H)-one selectively retards cell cycle in lettuce root meristems. Phytochem. 69:2132
Sánchez-Moreiras A-M (2011) Early senescence induced by 2-3H-benzoxazolinone (BOA) in Arabidopsis thaliana. et al. J Plant Physiol. 168:863