SKU: B089  / 
    CAS Number: 59-49-4

    2-Benzoxazolinone

    $55.64 - $194.76

    2-Benzoxazolinone is a metabolite produced by rye (Secale cereale) that inhibits germination and growth and causing oxidative damage.  2-Benzoxazolinone has diverse pharmacological activities including antinociception, anti-inflammatory, antileishmanial, antioxidant, anti-HIV, anticancer, antidepressant, and neuroprotective effects. 2-Benzoxazolinone is a sought-after structure for the design of bioactive molecules.  2-Benzoxazolinone is soluble in methanol and DMSO.

    Molecular Formula  C7H5NO2
    Mechanism of Action 2-Benzoxazolinone targets the G2/M phase of the cell cycle.  
    Plant Biology The natural compound inhibits the cell cycle in lettuce root meristems (Sanchez et al, 2008).  Early senescence is induced by 2-3H-benzoxazolinone (BOA) in Arabidopsis thaliana (Sanchez et al, 2011).
    References

    Sánchez-Moreiras A-M (2008)  The natural compound benzoxazolin-2(3H)-one selectively retards cell cycle in lettuce root meristems. Phytochem. 69:2132

    Sánchez-Moreiras A-M (2011)  Early senescence induced by 2-3H-benzoxazolinone (BOA) in Arabidopsis thaliana. et al. J Plant Physiol. 168:863