4-Epitetracycline ammonium salt, EvoPure® is a highly purified version of 4-Epitetracycline, an epimer of Tetracycline. Tetracycline is a broad-spectrum antibacterial and selection agent.
We also offer:
4-Epitetracycline Hydrochloride, EvoPure® (T053).
| Mechanism of Action | Under acid conditions, Tetracycycline undergoes a reversible epimerization at the fourth carbon, producing a mixture of tetracycline and 4-Epitetracycline. Tetracycline inhibits the growth of Gram-positive and Gram-negative bacteria by disrupting codon-anticodon interactions at the ribosome, thus blocking protein synthesis. Specifically, Tetracycline binds to the 30S ribosomal subunit and blocks the attachment of charged aminoacyl-tRNA to the A site on the ribosome, preventing peptide elongation. |
| Spectrum | Effective against Gram-positive and Gram-negative bacteria, and Mycoplasma. |
| Microbiology Applications | 4-epitetracycline ammonium salt, EvoPure® can be use as an analytical standard. |
| Molecular Formula | C22H27N3O8 |
| References | Mazur X, Eppenberger HM, Bailey JE and FUssenegger M (2000) A novel autoregulated proliferation-controlled production process using recombinant CHO cells. Biotechnol and Bioeng. 65(2):144-150 Fernandez AA, Noceda VT, Carrera ES (1969) Simultaneous separation and quantitative determination of tetracycline, anhydrotetracycline, 4-epitetracycline, and 4-epi-anhydrotetracycline in degraded tetracyclines by thin-layer chromatography. J. Pharm. Sci. 58(4):443-446 |
