SKU: T056  / 
    CAS Number: 4465-65-0

    4-Epianhydrotetracycline HCl, EvoPure®


    4-epianhydrotetracycline HCl (tetracycline impurity D) is a degredation compound of the polyketide antibiotic, tetracycline. 4-epianhydrotetracycline is thought to form in samples of improperly stored tetracycline especially in warm, moist, and acidic environments. Studies using rats have shown 4-epianhydrotetracycline to cause renal toxicity and a decrease in mitochondrial respiration.

    Molecular FormulaC22H22N2O7 · xHCl (lot specific)

    Benitz, K. F., and H. F. Diermeier. "Renal Toxicity of Tetracycline Degradation Products." Experimental Biology and Medicine 115.4 (1964): 930-35. Web. 7 May 2013.

    Fike, Winston W., and Nicholas W. Brake. "Modified Method for Determining Tetracycline, 4-epitetracycline, and Anhydrotetracyclines in Tetracycline Base or Hydrochloride." Journal of Pharmaceutical Sciences 61.4 (1972): 615-17. Web. 7 May 2013.