A 54556A is an unusual depsipeptide isolated from Streptomyces hawaiiensis by researchers at Eli Lilly in 1985, featuring a trienone side chain. A 54556A is potently active against Gram positive and Gram negative bacteria, including MRSA. ADEPs are considered important leads in the development of new generations of antibiotics against resistant bacteria.
A 54556A is soluble in ethanol, methanol, DMF and DMSO.
A 54556A is soluble in ethanol, methanol, DMF and DMSO.
| Mechanism of Action | A 54556A acts by activating and dis-regulating Clp-family proteins. |
| Molecular Formula | C38H50N6O8 |
| References | A54556 antibiotics and process for production thereof. Michel K.H. and Kastner R.E. U.S. Patent 4,492,650 1985. Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism. Lee B-G. et al. Nat. Struct. Molec. Biol. 2010, 17, 471. Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ. Sass P. et al. PNAS 2011, 108, 17474. |