Acetoxypolygodial is a drimane sesquiterpene isolated from the leaves and stems of Tasmannia lanceolata and bark of Canella winterana, and present in other plant species. Acetoxypolygodial is antifungal and weakly cytotoxic, and is potently active against Plasmodium falciparum (IC50 2.53 ug/mL).
Deans RM et al (2014) Isolation and characterization of 1β-acetoxypolygodial from Tasmannia lanceolata. Asian J. Org. Chem. 3:1193
Grace MH et al (2010) Antiplasmodial and cytotoxic activites of drimane sesquiterpenes from Canella winterana. Nat. Prod. Commun. 5:1869