SKU: A201  / 
    CAS Number: 57576-44-0

    Aclarubicin

    ₱13,269.59 - ₱46,465.59

    Aclarubicin (aclacinomycin A) is an anthracycline and topoisomerase II inhibitor that has been clinically tested against haematologic and solid tumors. Aclarubicin stabilizes topoisomerase I cleavage. Aclarubicin accumulates efficiently in the mitochondria of living human cells and leads to mitochondrial dysfunction. Aclarubicin inhibits reverse transcriptase, endothelin converting enzyme and collagenase, and is active against HIV.

    Molecular Formula  C42H53NO15
    References

    Beck WT et al (1994)  Novel actions of inhibitors of DNA topoisomerase II in drug-resistant tumor cells. Cancer Chemother Pharmacol. 34 Suppl:S14-8.

    Hori S et al (1977)  Antitumor activity of new anthracycline antibiotics, aclacinomycin-A and its analogs, and their toxicity. Gan 68:685

    Iihoshi H et al (2017)  Aclarubicin, an anthracycline anti-cancer drug, fluorescently contrasts mitochondria and reduces the oxygen consumption rate in living human cells. Toxicol. Lett. 277:109