Actinopyrone A is a gamma-pyrone compound isolated from a Streptomyces sp. It shows selective (>106 fold) and potent (MIC=0.0001 µg/ml) activity against Helicobacter pylori, the principal cause of peptic ulcer disease. Actinopyrone A was originally identified for its coronary vasodilating activity and weak activity against some Gram-positive bacteria and dermatophytes.
Actinopyrone A is soluble in ethanol, methanol, DMF and DMSO.
| References | Taniguchi M et al (2000) Gamma-Pyrone compounds with selective and potent anti-Helicobacter pylori activity. J. Antibiotics, 53:844 Yano K et al (1986) Actinopyrones A, B and C, new physiologically active substances. I. Producing organism, fermentation, isolation and biological properties. J. Antibiotics 39:32 Yano K et al (1986) Actinopyrones A, B and C, new physiologically active substances. II. Physico-chemical properties and chemical structures. J. Antibiotics 39:38 |