SKU: A085  / 
    CAS Number: 6398-98-7

    Amodiaquine Hydrochloride


    Amodiaquine Hydrochloride is a synthetic,4-aminoquinoline compound with anti-malarial and anti-inflammatory properties.  It is a histamine-N-methyltransferase inhibitor that was developed in 1948.  Amodiaquine Hydrochloride is a congener of chloroquine and its mechanism of action is similar.  Its active metabolite is N-desethylamodiaquine. 

    Amodiaquine Hydrochloride is soluble in DMSO.

    Mechanism of Action The mechanism of action for Amodiaquine is not entirely clear; however, it is thought to inhibit digestion of hemoglobin in malarial parasites, inhibiting heme polymerase activity.  The result is an accumulation of free heme, which is toxic to the parasite. 
    Spectrum Amodiaquine has a similar spectrum of activity as chloroquine (Plasmodium vivax, Plasmodium malariae) however; it has shown to be more effective against chloroquine-resistant Plasmodium falciparum.
    Molecular Formula C20H22ClN3O •2HCl •2H2O
    Impurities Individual Impurity: ≤0.5%
    Total Impurities: ≤1.0%

    Ahmad I, Ahmad T and Usmanghani K (1992)  Amodiaquine Hydrochloride. In: Analytical profiles of drug substances and excipients. 21:43-73

    Wennerholm et al (2006)  Amodiaquine, its desethylated metabolite, or both, inhibit the metabolism of debrisoquine (CYP2D6) and losartan (CYP2C9) in vivo. Eur. J. Clin. Pharmacol. 62:539–546