Amodiaquine Hydrochloride is a synthetic,4-aminoquinoline compound with anti-malarial and anti-inflammatory properties. It is a histamine-N-methyltransferase inhibitor that was developed in 1948. Amodiaquine Hydrochloride is a congener of chloroquine and its mechanism of action is similar. Its active metabolite is N-desethylamodiaquine.
Amodiaquine Hydrochloride is soluble in DMSO.
|Mechanism of Action||The mechanism of action for Amodiaquine is not entirely clear; however, it is thought to inhibit digestion of hemoglobin in malarial parasites, inhibiting heme polymerase activity. The result is an accumulation of free heme, which is toxic to the parasite.|
|Spectrum||Amodiaquine has a similar spectrum of activity as chloroquine (Plasmodium vivax, Plasmodium malariae) however; it has shown to be more effective against chloroquine-resistant Plasmodium falciparum.|
|Molecular Formula||C20H22ClN3O •2HCl •2H2O|
|Impurities||Individual Impurity: ≤0.5%
Total Impurities: ≤1.0%
Ahmad I, Ahmad T and Usmanghani K (1992) Amodiaquine Hydrochloride. In: Analytical profiles of drug substances and excipients. 21:43-73
Wennerholm et al (2006) Amodiaquine, its desethylated metabolite, or both, inhibit the metabolism of debrisoquine (CYP2D6) and losartan (CYP2C9) in vivo. Eur. J. Clin. Pharmacol. 62:539–546