SKU: A013  / 
    CAS Number: 37321-09-8

    Apramycin

    Mex$1,921.50 - Mex$6,667.50

    Apramycin is a structurally unique broad-spectrum aminoglycoside with a bicyclic sugar moiety and a monosubstituted deoxystreptamineactive. Apramycin inhibits the translocation step of bacterial protein synthesis and induces translation errors. Apramycin is marketed for veterinary use for Gram negative bacteria. Resistance to Apramycin is conferred by production of ribosomal acetyltransferase.

    Molecular Formula  C21H41N5O11

    References

     

    Hedges RW and Shannon KP (1984)  Resistance to Apramycin in Escherichia coli isolated from animals: Detection of a novel aminoglycoside-modifying enzyme.  J. Gen. Microbiol. 130:473

    O'Connor S et al (1976)  Apramycin, a unique aminocyclitol antibiotic.  J. Org. Chem. 1:2087

    Perzynski S et al (1979)  Effects of apramycin, a novel aminoglycoside antibiotic on bacterial protein synthesis.  Eur. J. Biochem. 99:623

    Walton JR (1978)  Apramycin, a new aminocyclitol antibiotic: I. In vitro microbiological studies.  J. Antimicrob. Chemother. 4:309