Apramycin is a structurally unique broad-spectrum aminoglycoside with a bicyclic sugar moiety and a monosubstituted deoxystreptamineactive. Apramycin inhibits the translocation step of bacterial protein synthesis and induces translation errors. Apramycin is marketed for veterinary use for Gram negative bacteria. Resistance to Apramycin is conferred by production of ribosomal acetyltransferase.
| Molecular Formula | C21H41N5O11 |
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References
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Hedges RW and Shannon KP (1984) Resistance to Apramycin in Escherichia coli isolated from animals: Detection of a novel aminoglycoside-modifying enzyme. J. Gen. Microbiol. 130:473 O'Connor S et al (1976) Apramycin, a unique aminocyclitol antibiotic. J. Org. Chem. 1:2087 Perzynski S et al (1979) Effects of apramycin, a novel aminoglycoside antibiotic on bacterial protein synthesis. Eur. J. Biochem. 99:623 Walton JR (1978) Apramycin, a new aminocyclitol antibiotic: I. In vitro microbiological studies. J. Antimicrob. Chemother. 4:309
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