SKU: A213  / 
    CAS Number: 153821-50-2

    Aquastatin A

    $181.00 - $632.50
    Aquastatin A

    Aquastatin A, produced by Fusarium sp., is an inhibitor of mammalian adenosine triphosphatases with an IC50 of 7.1 µM against Na+/K+-ATPase 6.2 µM against H+/K+-ATPase. Aquastatin A is a potent inhibitor of enoyl-ACP reductase (FabI) of Staphylococcus aureus and is active against MRSA. Aquastatin A was patented for the treatment of gastric ulcers in 1994.

    Molecular Formula  C36H52O12
    References

    Hamano K et al (1993)  Aquastatin A, an inhibitor of mammalian adenosine triphosphatases from Fusarium aquaeductuum. Taxonomy, fermentation, isolation, structure determination and biological properties.  J Antibiot 46:1648

    Hamano et al (1994)  Aquastatin A manufacture with Fusarium for use in treatment of gastric ulcers. Jpn. Kokai Tokkyo Koho JP 06247900 A 19940906

    Kwon Y (2009)  Aquastatin A, a new inhibitor of enoyl-acyl carrier protein reductase from Sporothrix sp. FN611.  Biol Pharm Bull 32:2061