Aquastatin A, produced by Fusarium sp., is an inhibitor of mammalian adenosine triphosphatases with an IC50 of 7.1 µM against Na+/K+-ATPase 6.2 µM against H+/K+-ATPase. Aquastatin A is a potent inhibitor of enoyl-ACP reductase (FabI) of Staphylococcus aureus and is active against MRSA. Aquastatin A was patented for the treatment of gastric ulcers in 1994.
| Molecular Formula | C36H52O12 |
| References |
Hamano K et al (1993) Aquastatin A, an inhibitor of mammalian adenosine triphosphatases from Fusarium aquaeductuum. Taxonomy, fermentation, isolation, structure determination and biological properties. J Antibiot 46:1648 Hamano et al (1994) Aquastatin A manufacture with Fusarium for use in treatment of gastric ulcers. Jpn. Kokai Tokkyo Koho JP 06247900 A 19940906 Kwon Y (2009) Aquastatin A, a new inhibitor of enoyl-acyl carrier protein reductase from Sporothrix sp. FN611. Biol Pharm Bull 32:2061
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