Aranciamycin A is an anthracycline bearing a methyl-L-rhamnose sugar in the 2-O position. Aranciamycin A has antitumor and Gram positive antibiotic activity and is a potent inhibitor of Clostridium histolyticum collagenase, with an IC50 = 3.7 x 10-7M.
| Molecular Formula | C26H28O10 |
| References |
Keller-Schierlein W et al (1970) Metabolites of microorganisms. Aranciamycin. Helv Chim Acta 53:779 Keller-Schierlein W and Muller A (1970) The sugar component of aranciamycin: 2-0-methyl-L-rhamnose. Experientia 26:929 Luzhetskyy A. et al (2008) Aranciamycin analogs generated by combinatorial biosynthesis show improved antitumor activity. Appl Microbiol Biotech 80:15 |