Arjunolic acid is a pentacyclic triterpenoid first isolated from the tropical hardwood, Terminalia arjuna, and its structure resolved by researchers at University of Nottingham, UK. Subsequently, Arjunolic Acid was found in a diverse range of hardwood species. Arjunolic Acid has antifungal, antibacterial, antioxidant, cardioprotectant and antitumor activity. Arjunolic acid stabilizes the ligand-binding domain of peroxisome proliferator-activated receptor-α (PPARα) and increases its expression during cardiac hypertrophy. Arjunolic Acid is potentially useful in the treatment of type 1 diabetes by preventing hyperglycemia-induced activation of MAPKs, PKC, NF-kB signaling cascades.
Bannon C.D. et al (1979) Extractives of Australian timbers. XVI. The constituents of the wood of Eugenia crebrinervis (syn. Syzigium crebrinerve) and Eugenia gustavioides (syn. Cleistocalyx gustavioides). Aust J. Chem. 29:1135
Bansal T e al (2017) Arjunolic acid, a peroxisome proliferator-activated receptor α agonist, regresses cardiac fibrosis by inhibiting non-canonical TGF-β signaling. J. Biol. Chem. 292:16440
Corbett RE and Bailey CR (1963) Extractives from the New Zealand Myrtaceae. VI. Arjunolic acid from the heartwood of Metrosideros umbellate.Aust. J. Chem. 16:191
Hemalatha T et al (2010) Arjunolic acid: a novel phytomedicine with multifunctional therapeutic applications. Indian J. Exp. Biol. 48:238
King FE et al (1954) The chemistry of extractives from hardwoods. XVIII. The constitution of arjunolic acid, a triterpene from Terminalia arjuna. J. Chem. Soc. 3995