SKU: A096  / 
    CAS Number: 88495-63-0

    Artesunate

    $20,175.60 - $69,427.80
    Artesunate is an anti-malarial drug and has been found to be effective against multidrug-resistant Plasmodium falciparum and P. vivax malaria. Artesunate has also been found to have anti-cancer activity against leukemia and colon cancer cell lines.
    Mechanism of ActionArtesunate causes double stranded breaks in parasite DNA which leads to a buildup of intracellular reactive oxygen species (ROS).
    SpectrumArtesunate is active against Plasmodium falciparum and P. vivax.
    Impurity ProfileSingle impurity: Not more than 0.5%
    Total impurities: Not more than 2.0%
    Molecular FormulaC19H28O8
    SolubilitySlightly soluble in water, freely soluble in ethanol, acetone, and chloroform
    Impurity ProfileSingle impurity: Not more than 0.5%
    Total impurities: Not more than 2.0%
    ReferencesEfferth, Thomas, Heather Dunstan, Axel Sauerbrey, Hayato Miyachi, and Christopher Chitambar. "The Anti-malarial Artesunate Is Also Active against Cancer." Int J Oncol International Journal of Oncology (2001): n. pag. Web.

    Gopalakrishnan, Anusha M., and Nirbhay Kumar. "Antimalarial Action of Artesunate Involves DNA Damage Mediated by Reactive Oxygen Species." Antimicrobial Agents and Chemotherapy Antimicrob. Agents Chemother. 59.1 (2014): 317-25. Web.