SKU: A016  / 
    CAS Number: 71774-51-1

    Aureonitol

    $219.65 - $769.16

    Aureonitol is a tetrahydrofuran isolated from Chaetomium sp. that acts like a transcriptional regulator for the biosynthesis of other secondary metabolites. The absolute configuration was confirmed in 2008. Aureonitol inhibits influenza A and B virus replication, being more effective against influenza A (H3N2) with EC50 of 100 nM. Aureonitol acts via inhibition of hemagglutination significantly impairing virus adsoption. Aureonitol has low cytoxicity with a IC50 value of 1426 μM.

    Molecular Formula  C13H18O2
    References

    Abraham WR and Arfmann H-A (1992)  Rearranged tetrahydrofurans from Chaetomium cochlioides.  Phytochem. 31:2405

    Jervis PJ and Cox LRJ (2008)  Total synthesis and proof of relative stereochemistry of (−)-aureonitol. J. Org. Chem. 73:7616

    Nakazawa T et al (2013)  Targeted disruption of transcriptional regulators in Chaetomium globosum activates biosynthetic pathways and reveals transcriptional regulator-like behavior of aureonitol.  J Am Chem Soc 135:13446