Avilamycin A is a chlorine-containing polysaccharide antibiotic produced by Streptomyces viridochromogenes. Avilamycin is active against Gram-positive bacteria and is used as a growth promotant and for prevention of necrotic enteritis in animals. Avilamycin binds to the 30S ribosome and resistance is conferred by rRNA methyl transferases. Avilamycin A is a major analog in the commercial product Surmax™.
| Molecular Formula | C61H88Cl2O32 |
| References |
Buzzetti F et al (1968) Avilamycin. Experientia 24:320 Weitnauer G et al (2001) An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tu57. Antimicrob. Agents Chemother. 45:690 Wolf H (1973) Avilamycin, an inhibitor of the 30 S ribosomal subunits function. FEBS Lett 36:181 |
