Avilamycin C is a chlorine-containing polysaccharide antibiotic produced by Streptomyces viridochromogenes. Avilamycin is active against Gram-positive bacteria and is used as a growth promotant and for prevention of necrotic enteritis in animals. Avilamycin binds to the 30S ribosome and resistance is conferred by rNA methyl transferases. Avilamycin C is a major analogue in the commercial product SurmaxTM.
| Molecular Formula | C61H90Cl2O32 |
| References |
Buzzetti F et al (1968) Avilamycin. Experientia 24:320 Weitnauer G et al (2001) An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to Avilamycin in the producer organism Streptomyces viridochromogenes Tu57. Antimicrob. Agents Chemother. 45:690 Wolf H et al (1973) Avilamycin, an inhibitor of the 30 S ribosomal subunits function. FEBS Lett 36:181 |
