SKU: A222  / 
    CAS Number: 269741-97-1

    Avrainvillamide

    $181.00 - $632.50

    Avrainvillamide is the monomer of the stephacidin B dimer. Avrainvillamide is active against the proto-oncogene, mutated NPM1, commonly present in patients with acute myeloid lukemia. Avrainvillamide alkylates Cys275 of mutated NPM1, inhibits nuclear export of Crm1 cargo proteins.  Aavrainvillamide also displaces Thr199-​phosphorylated NPM1 from duplicated centrosomes, leads to an accumulation of supernumerary centrosomes and inhibits dephosphorylation of Thr199-​phosphorylated NPM1 by protein phosphatase 1.  

    Molecular Formula  C26H27N3O4
    References

    Sugie Y et al (2001)  A new antibiotic CJ-17,665 from Aspergillus ochraceus. J. Antibiot. 54:911

    Vibeke A et al (2016)  Anti-​proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia. Cell death and Disease 7:e2497

    Wulff JE et al (2007)  The natural product avrainvillamide binds to the oncoprotein nucleophosmin. J. Am. Chem. Soc. 129:14444