SKU: A023  / 
    CAS Number: 37091-65-9

    Azlocillin Sodium

    $72.51 - $280.72

    Azlocillin sodium is an extended spectrum ë_-lactam antibiotic derived from ampicillin. Azlocillin sodium is freely soluble in aqueous solution (50 mg/mL).

    Mechanism of Actionβ-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded ESBLs (Extended Spectrum β-lactamases).
    SpectrumMembers of the gram negative bacteria including Pseudomonas aeruginosa, Haemophilus influenzae, and Escherichia coli are common targets of azlocillin sodium.
    Microbiology ApplicationsAzlocillin sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Pseudomonas aeruginosa 0.5 µg/mL – 512 µg/mL
    • Escherichia coli 0.03 µg/mL - 2 µg/mL
    • For a complete list of azlocillin MIC values, click here.
    Molecular FormulaC20H22N5NaO6S

    References

    Guzmán, Flavio, MD. "Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.

    Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 1997; 103:51.

    MICBacteroides fragilis| 1 - 16|| Borrelia afzelii| ≤0.125|| Borrelia bissettii (25015)| ≤0.125|| Borrelia burgdorferi| ≤0.125|| Borrelia garinii| ≤0.125|| Borrelia valaisiana (VS116)| ≤0.125|| Citrobacter diversus| 4 - 128|| Citrobacter freundii | 1 - 64|| Edwardsiella hoshinae | 0.25 - 0.5|| Edwardsiella ictaluri | 0.25 - 4|| Edwardsiella tarda| 0.25 - 8|| Enterobacter cloacae| 2 - 256|| Enterobacteriaceae| 0.25 - 128|| Escherichia coli| 1 - 32|| Haemophilus spp.| 0.03 - 2|| Klebsiella pneumonia| 1 - 8|| Morganella morganii| 0.5 - 32|| Neisseria spp.| 0.004 - 8|| Proteus vulgaris| 8 - 32|| Pseudomonas aeruginosa| 4 - 6.25|| Pseudomonas spp.| 0.5 - 512|| Salmonella typhimurium| 16|| Serratia marcescens| 2 - 50|| Staphylococci| 0.06 - 128|| Staphylococcus aureus| 0.25 - 16|| Stenotrophomonas maltophilia| 25||