Baicalin is a glycosyloxyflavone isolated from Scutellaria baicalensis Georgi and has demonstrated anti-viral and anti-inflammatory properties. This plant species and its primary constituents including Baicalin were found to have potent inhibitory activity against various viruses, including influenza.
Baicalin is soluble in DMSO and DMF. It is very slightly soluble in water and ethanol.
| Spectrum | Baicalin has been shown to have in vivo and in vitro inhibitory properties against influenza virus. |
| Microbiology Applications |
Baicalin could induce Interferon-gamma (IFN-γ) production in human CD4+ and CD8+ T cells and NK cells, and activate Janus Kiinase (JAK)/Signal Transducer and Activator of Transcription 1(STAT-1) signaling pathway. Baicalin exhibited anti-influenza virus A (H1N1) activity in vitro (and in vivo) as a potent inducer of IFN-γ in major IFN-γ producing cells. In traditional Chinese medicine, Scutellaria is a medicinal herb used to treat colds, an illness usually caused by influenza virus. In 1990, a flavone isolated from Scutellaria baicalensis Georgi was shown to possess a potent antiviral activity against influenza virus. Its primary constituents including Baicalin were found to have inhibitory activities against various viruses (Li et al, 2014). |
| Plant Biology Applications |
Scutellaria baicalensis Georgi is one of the fundamental herbs used in traditional Chinese medicine used to treat colds. Its common name is Baikal skullcap or Chinese skullcap (Huang-chin) is a species of flowering plant belonging to the family Lamiaceae. Baicalin is one of the four major flavones isolated from this herb, along with Wogonin, Wogonoside, and Baicalein. |
| Cancer Applications |
Biacalin has anti-proliferative activity against various cancers including breast, colon, hepatic, leukemia, lung, and skin. This plant-sourced anticancer phytochemical reduced cancer cell proliferation and has the potential to reduce cancer progression both in in vitro and in vivo models of different types of cancer (Singh et al, 2021). |
| Molecular Formula | C21H18O11 |
| References |
Li C, Feng L, Zhang Z and and Jia X (2014) The anti-inflammation effect of Baicalin on experimental colitis through inhibiting TLR4/NF-κB pathway activation. Int. Immunopharm. 23(1):294-303 Singh S, Meena A, Luqman S (2021) Baicalin mediated regulation of key signaling pathways in cancer. Pharmacol. Res. 164:105387 PMID 33352232 |