Beauvericin is a cyclic depsipeptide isolated from several fungal genera, notably Beauveria and Fusarium, first reported in 1969. Beauvericin exhibits broad antifungal, antibacterial, antiprotozoan and insecticidal activities.
Beauvericin is soluble in ethanol, methanol, DMF and DMSO.
Beauvericin is soluble in ethanol, methanol, DMF and DMSO.
| Mechanism of Action | At the molecular level, beauvericin exhibits ionophore properties, and inhibits acyl-CoA:cholesterol acyltransferase activity. Beauvericin induces apoptosis by elevating intracellular calcium levels. |
| Molecular Formula | C45H57N3O9 |
| References | The structure of beauvericin, a new depsipeptide antibiotic toxic to Artemia salina. Hamill Z. R. L. et al. Tet. Letters 1969, 4255. Inhibition of acyl-CoA:cholesterol acyltransferase activity by cyclodepsipeptide antibiotics. Tomoda H. et al. J. Antibiot. 1992, 45, 1626. Beauvericin Production by Fusarium Species. Logrieco A. et al. Appl. Environ. Microbiol. 1998, 64, 3084. |
