Berkleylactone F is a major analog of a family of recently described macrolide antibiotics, isolated from a mixed fermentation of two Penicillium species. Berkleylactone F is active against Gram-positive bacteria, Candida albicans and Candida glabrata, with an undescribed but purportedly novel mode of action. Berkeleylactone F is an analog of A 26771B.
| Molecular Formula | C16H28O5 |
| References | Michel KH et al (1977) The isolation and structure elucidation of macrocyclic lactone antibiotic, A26771B. J. Antibiot. 30:571 Stierle AA et al (2017) The berkeleylactones, antibiotic macrolides from fungal coculture. J. Nat. Prod. 80:1150 |
