Berkleylactone F is a major analog of a family of recently described macrolide antibiotics, isolated from a mixed fermentation of two Penicillium species. Berkleylactone F is active against Gram-positive bacteria, Candida albicans and Candida glabrata, with an undescribed but purportedly novel mode of action. Berkeleylactone F is an analog of A 26771B.
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Stierle AA et al (2017) The berkeleylactones, antibiotic macrolides from fungal coculture. J. Nat. Prod. 80:1150