SKU: B046  / 
    CAS Number: 58798-97-3

    Berninamycin A

    $277.35 - $970.71
    Berninamycin A is an antibiotic discovered in 1976 from a strain of Streptomyces. Berninamycin A is a macrocyclic 'peptide' comprising atypical amino acids linked to thiazole and oxazoles. Berninamycin A is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.

    Berninamycin A is soluble in DMF and DMSO. 
    Mechanism of ActionChemically very complex, berninamycin A is an inducer of tipA, a gene that controls the bacterial transcription regulators, TipAL and TipAS, that are central to multidrug resistance.
    Molecular FormulaC51H51N15O15S
    ReferencesBerninamycin. I. The structure of berninamycinic acid. Liesch, J.M. et al. , J.Am.Chem.Soc. 1976, 98, 299. 

    Mode of action of berninamycin. An inhibitor of protein biosynthesis. Reusser F. Biochem. 1969, 8, 3303. 

    Identification of a chemical inhibitor of the oncogenic transcription factor Forkhead Box M1. Radhakrishnan et al. , Cancer Res. 2006, 19, 9731.