Bestatin is 'pseudo'-dipeptide isolated from Streptomyces olivreticuli in 1976. Bestatin is a potent aminopeptidase B inhibitor with no carboxypeptidase activity. Bestatin also exhibits antitumor activity and has been investigated in clinical trials.
Bestatin is soluble in ethanol, methanol, DMF and DMSO and is moderately soluble in water.
Bestatin is soluble in ethanol, methanol, DMF and DMSO and is moderately soluble in water.
| Mechanism of Action | Bestatin acts as an immunomodulator by activating macrophages and T lymphocytes. |
| Molecular Formula | C16H24N2O4 |
| References | Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes. Umezawa H. et al. J. Antibio. 1976, 29, 97. The structure of bestatin. Suda H.. et al. J. Antibio. 1976, 29, 100. Low-molecular-weight enzyme inhibitors of microbial origin. Umezawa H. Ann. Rev. Microbiol. 1982, 36, 75. |