SKU: B019  / 
    CAS Number: 11116-31-7 (Bleomycin A2 base)

    Bleomycin A2 sulfate, EvoPure®

    $486.68

    Bleomycin A2 Sulfate, EvoPure® is a glycopeptide antibiotic used as a chemotherapeutic agent in the treatment of Hodgkin's lymphoma. Bleomycin A2 is structurally similar to the other compound found in Bleomycin (Bleomycin B2)  and differs only by a terminal amine group. 

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    Mechanism of ActionThe exact mechanism of action is not well defined; however, it is thought to chelate metallic ions to decrease enzyme activity and stability. This effect is believed to cause enzymes to react with oxygen producing free radicals which cause single-strand breaks in deoxyribose sugar.
    Plant Biology ApplicationsBleomycin has been used in gene selection of tobacco, as only plants containing the Ble resistance gene were able to survive in the presence of Bleomycin (Miki et al, 2003).
    Molecular FormulaC55H84N17O21S3 · xH2SO4 (lot specific)
    References

    Kole, C., Michler C.H., Abbott A.G. and Hall C.T. 2010. Transgenic Crop Plants: Volume 1: Principles and Development. Springer

    Miki B., McHugh S., 2003 Selectable marker genes in transgenic plants: applications, alternatives and biosafety. Journal of Biotechnology 107 (2004) 193–232.

    Dorr, R. T. "Bleomycin Pharmacology: Mechanism of Action and Resistance, and Clinical Pharmacokinetics." Seminars in Oncology 19.2 (1992): 3-8. Ncbi.gov. Web. 11 Sept. 2012.

    "Monographs: Pharmaceutical Substances: Bleomycini Hydrochloridum - Bleomycin Hydrochloride." The International Pharmacopoeia. N.p., n.d. Web. 16 Jan. 2013.