Bleomycin A2 Sulfate, EvoPure® is a glycopeptide antibiotic used as a chemotherapeutic agent in the treatment of Hodgkin's lymphoma. Bleomycin A2 is structurally similar to the other compound found in Bleomycin (Bleomycin B2) and differs only by a terminal amine group.
EvoPure® products have been fully characterized by spectral analysis and are shipped with a comprehensive certificate of analysis containing lot-specific HPLC, MS, HNMR, and FTIR data.
We also offer:
- Bleomycin B2 Sulfate, EvoPure® (B020)
- Bleomycin Sulfate (B005)
- Demethylbleomycin A2 Sulfate, EvoPure® (D023)
|Mechanism of Action||The mechanism of action of Bleomycin is not well defined; however, it is thought to chelate metallic ions to decrease enzyme activity and stability. This effect is believed to cause enzymes to react with oxygen producing free radicals which cause single-strand breaks in deoxyribose sugar.|
|Plant Biology Applications||Bleomycin has been used in gene selection of tobacco, as only plants containing the ble resistance gene were able to survive in the presence of Bleomycin (Miki et al, 2003).|
|Molecular Formula||C55H84N17O21S3 · xH2SO4 (lot specific)|
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Miki B and McHugh S (2003) Selectable marker genes in transgenic plants: Applications, alternatives and biosafety. J. Biotechnol. 107:193–232
Dorr RT (1992) Bleomycin Pharmacology: Mechanism of action and resistance, and Clinical Pharmacokinetics. Seminars in Oncology 19(2):3-8
Monographs: Pharmaceutical Substances: Bleomycin Hydrochloridum - Bleomycin Hydrochloride. The International Pharmacopoeia