Bleomycin A2 Sulfate, EvoPure® is a glycopeptide antibiotic used as a chemotherapeutic agent in the treatment of Hodgkin's lymphoma. Bleomycin A2 is structurally similar to the other compound found in Bleomycin (Bleomycin B2) and differs only by a terminal amine group.
We also offer:
- Bleomycin A2 sulfate, EvoPure® (B019)
- Bleomycin B2 sulfate, EvoPure® (B020)
- Bleomycin sulfate (B005)
- Demethylbleomycin A2 sulfate, EvoPure® (D023)
|Mechanism of Action||The exact mechanism of action is not well defined; however, it is thought to chelate metallic ions to decrease enzyme activity and stability. This effect is believed to cause enzymes to react with oxygen producing free radicals which cause single-strand breaks in deoxyribose sugar.|
|Plant Biology Applications||Bleomycin has been used in gene selection of tobacco, as only plants containing the Ble resistance gene were able to survive in the presence of Bleomycin (Miki et al, 2003).|
|Molecular Formula||C55H84N17O21S3 · xH2SO4 (lot specific)|
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Miki B., McHugh S., 2003 Selectable marker genes in transgenic plants: applications, alternatives and biosafety. Journal of Biotechnology 107 (2004) 193–232.
Dorr, R. T. "Bleomycin Pharmacology: Mechanism of Action and Resistance, and Clinical Pharmacokinetics." Seminars in Oncology 19.2 (1992): 3-8. Ncbi.gov. Web. 11 Sept. 2012.
"Monographs: Pharmaceutical Substances: Bleomycini Hydrochloridum - Bleomycin Hydrochloride." The International Pharmacopoeia. N.p., n.d. Web. 16 Jan. 2013.