Bleomycin A2 Sulfate, EvoPure® is a glycopeptide antibiotic used as a chemotherapeutic agent in cancer research studies including Hodgkin's lymphoma. Bleomycin A2 is structurally similar to the other compound found in Bleomycin (Bleomycin B2) and differs by a terminal amine group.
EvoPure® products have been fully characterized by spectral analysis and are shipped with a comprehensive certificate of analysis containing lot-specific HPLC, MS, HNMR, and FTIR data.
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| Mechanism of Action | The mechanism of action of Bleomycin is not well defined; however, it is thought to chelate metallic ions to decrease enzyme activity and stability. This effect is believed to cause enzymes to react with oxygen producing free radicals which cause single-strand breaks in deoxyribose sugar. |
| Plant Biology Applications | Bleomycin has been used in gene selection of tobacco, as only plants containing the ble resistance gene were able to survive in the presence of Bleomycin (Miki et al, 2003). |
| Molecular Formula | C55H84N17O21S3 · xH2SO4 (lot specific) |
| References |
Dorr RT (1992) Bleomycin Pharmacology: Mechanism of action and resistance, and Clinical Pharmacokinetics. Seminars in Oncology 19(2):3-8 Kole C, Michler CH, Abbott AG and Hall CT (2010) Transgenic Crop Plants: Volume 1: Principles and Development. Springer Miki B and McHugh S (2003) Selectable marker genes in transgenic plants: Applications, alternatives and biosafety. J. Biotechnol. 107:193–232 Monographs: Pharmaceutical Substances: Bleomycin Hydrochloridum - Bleomycin Hydrochloride. The International Pharmacopoeia |
