SKU: B041  / 
    CAS Number: 7184-60-3

    Borrelidin

    ¥21,916.62 - ¥76,713.50
    Borrelidin is an unusual nitrile-containing metabolite isolated from Streptomyces. Borrelidin is an important lead for antimalarial discovery, displaying activity against drug-resistant Plasmodia.

    Borrelidin is soluble in ethanol, methanol, DMF and DMSO.
    Mechanism of ActionBorrelidin is a selective inhibitor of bacterial and eukaryal threonyl-tRNA synthetase and is a very potent angiogenesis inhibitor and induces apoptosis of the capillary tube-forming cells.
    ReferencesA unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition among threonyl-tRNA synthetases. Ruan T. et al. , J. Biol. Chem. 2005, 280, 571. 

    Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model. Wakabayashi T. et al. , J. Antibiot. 1997, 50, 671.

    Anti-angiogenesis effects of borrelidin are mediated through distinct pathways: threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cells. Kawamura T. et al. , J. Antibiot. 2003, 56, 709.