SKU: C161  / 
    CAS Number: 121263-19-2

    Calphostin C

    5,752,665.88₫ - 20,134,959.78₫
    Calphostin C (PKF115-584) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides and inhibits cell proliferation and induces apoptosis in vitro.

    Calphostin C is soluble in ethanol, methanol, DMF and DMSO.
    Mechanism of ActionCalphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumor cell lines.
    ReferencesCalphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities. Kobayashi E. et al. , J. Antibiotics, 1989, 42, 1470. 

    Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures. Kobayashi E. et al. , J. Antibiotics, 1989, 42, 1475. 

    Inhibition of protein kinase C by calphostin C is light-dependent. Bruns R.F. et al. , Biochem. Biophys. Res. Commun., 1991, 176, 288. 

    Growth inhibition induced by Ro 31-8220 and calphostin C in human glioblastoma cell lines is associated with apoptosis and inhibition of CDC2 kinase. Begemann M. et al. , Anticancer Res., 1998, 18, 3139.

    Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Lepourcelet M. et al. Cancer Cell. 2004, 5, 91.