Camptothecin sodium is an alkaloid topoisomerase l (topo l) inhibitor with anticancer properties. Camptothecin sodium is isolated from either Camptotheca acuminata, a deciduous tree; or Nothapodytes foetida; a fungus.
|Mechanism of Action||Camptothecin sodium inhibits DNA religation in the cleavage/religation step by binding to DNA topoisomerase I (topo I) and DNA which forms a DNA topoisomerase I - camptothecin - DNA complex. This complex causes DNA damage and leads to apoptosis.|
|Cancer Applications||Camptothecin has poor water solubility and several camptothecin analogs and derivatives have been synthesized in an attempt to improve water solubility, bioavailability, and lactone stability.|
|References||Venditto, Vincent J. "Cancer Therapies Utilizing the Camptothecins: A Review of the in Vivo Literature." American Chemical Society (2010): 307-49. Web.|