Capreomycin is a complex of cyclic pentopeptides isolated from Streptomyces capreolus, first reported in 1962. The complex has two major components, IA and IB, with an exocyclic lysine residue and two minor delysinyl components, IIA and IIB. Capreomycin is a potent antibiotic with activity against mycobateria, Gram positive and Gram negative organisms.
Capreomycin is soluble in ethanol, methanol, DMF and DMSO.
Capreomycin is soluble in ethanol, methanol, DMF and DMSO.
| Mechanism of Action | Capreomycin acts by binding to the 23S ribosomal subunit, disrupting protein synthesis. |
| Molecular Formula | C25H44N14O7 (for IB) |
| References | Chemical and biological properties of capreomycin and other peptide antibiotics. Herr E.B. Antimicrob. Agents Chemother. 1962, 1963, 201. Molecular basis for the selectivity of antituberculosis compounds capreomycin and viomycin. Akbergenov R. et al. Antimicrob. Agents Chemother. 2011, 55, 4712. |
