Carbazomycin B is the dominant analogue of a family of rare carbazoles initially isolated from an unidentified Streptomyces sp. by researchers at Hiroshima University in 1980. Carbazomycin B is a 5-lipoxygenase inhibitor and free radical scavenger. Carbazomycin B is active against range of Gram positive bacteria and is weakly active against fungi and yeast. Like all carbazomycins, carbazomycin B possesses a highly distinct UV spectrum and can be readily identified and dereplicated by HPLC DAD. The mode of action of carbazomycins has received little attention.
| Molecular Formula | C15H15NO2 |
| References |
Hook D et al (1990) Identification of the inhibitory activity of carbazomycins B and C against 5-lipoxygenase, a new activity for these compounds. J. Antibiot. 43:1347 Kato et al (1993) In vitro and ex vivo free radical scavenging activities of carazostatin, carbazomycin B and their derivatives. J. Antibiot. 46:1859 Sakano K et al (1980) New antibiotics, carbazomycins A and B. I. Fermentation, extraction, purification and physico-chemical and biological properties. J. Antibiot. 33:683 |
